conjugated linoleic acid side effects

Published 2015 Sep 17. doi:10.1186/s12970-015-0097-4, Chen SC, Lin YH, Huang HP, Hsu WL, Houng JY, Huang CK. We'll assume you're ok with this, but you can opt-out if you wish. Read user ratings and reviews for CONJUGATED LINOLEIC ACID CLA on WebMD including side effects and interactions, treatment effectiveness, ease of use, safety and satisfaction. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. “ Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. CLA contains a mixture of different chemical forms -- or isomers -- of linoleic acid, a type of fat your body needs to function properly. ", Besides these disappointing results, other research in 2004 shows CLA may actually be harmful in some people. As CLA is naturally occurring, it comes as no surprise that side effects are infrequent and usually mild. We hope you enjoy this website. Unlike linoleic acid, which is found in various vegetable oils, CLA is primarily found in meat and dairy products. People taking a CLA supplement saw a decrease in body fat that was less than a half percentage point lower than those not taking the pill., A 2015 review study showed mixed results. In another report from 2007, researchers evaluated the results from 18 studies where participants took the supplement for a longer period of time (six months to two years). You also have the option to opt-out of these cookies. CLA is linoleic acid, a type of omega-6 fatty acid that occurs naturally in the body and in certain foods, mostly in meat and dairy products as per a study conducted by Banni S., Ph.D., Department of Experimental Biology, Experimental Pathology Section, University of Cagliari, Italy. CLA is mainly metabolized in the liver. These may indicate that you should stop taking the supplement. These cookies will be stored in your browser only with your consent. Keep in mind that dietary supplements haven't been tested for safety and due to the fact that they're largely unregulated, the content of some products may differ from what's specified on the product label. J Strength Cond Res. 2015;12:4. doi:10.1186/1743-7075-12-4, Namazi N, Irandoost P, Larijani B, Azadbakht L. The effects of supplementation with conjugated linoleic acid on anthropometric indices and body composition in overweight and obese subjects: A systematic review and meta-analysis. Conjugated Linoleic Acid (CLA) is a mix of specific fatty acids that belongs to that exclusive group of fats that provides a host of health benefits. The Ketogenic Diet Is The Fat Burning Diet, Boost Your Immune System With the Right Diet. To find more effectiveness of the fatty acid, the user should have at least 3,400 milligrams a day. iv. The word conjugated is the arrangement of double bonds in the fatty acid molecules. There's a wide range of other purported benefits as well, including cancer prevention and the treatment of high cholesterol. There are several side effects associated with conjugated linoleic acid. Aspirin 4. You can get tips on using supplements here, but if you're considering the use of CLA supplements, talk with your primary care provider first. Good cholesterol is necessary for keeping the LDL or ‘bad’ cholesterol in control. She is the author of "The Thyroid Diet Revolution. By using Verywell Health, you accept our, Lana Butner, ND, LAc, is a board-certified naturopathic doctor and licensed acupuncturist in private practice in New York City, Health Benefits of Chromium Polynicotinate, The Health Benefits of Collagen Supplements, The Many Health Benefits of Caprylic Acid, 4 Benefits of the Medicinal Mushroom Cordyceps, Flaxseed Oil: Benefits, Side Effects, Dosage, and Interactions, Guggul Extract and Its Possible Health Benefits, PCOS and Berberine: What Women Should Know. Effects of 6 weeks of aerobic exercise combined with conjugated linoleic acid on the physical working capacity at fatigue threshold. J Strength Cond Res. For example, in obese men with metabolic syndrome or at high risk for heart disease, CLA supplementation caused insulin resistance, a silent blood sugar problem that increases the risk for prediabetes, type 2 diabetes, and a host of other serious health problems, including heart attacks, strokes, and cancer., What's more, trans-10, cis-12, the key component of CLA supplements, was found to have a negative impact on blood sugar and could potentially contribute to the development of insulin resistance and atherosclerosis (hardening of the arteries)., Beyond its use in weight loss, proponents of CLA supplementation believe that it can enhance athletic performance in various ways, including stimulating testosterone production in the Leydig cells of the testicles. Other health benefits for CLA supplementation are also largely unsupported, including its use in treating diabetes, the common cold, allergic rhinitis (hay fever), or asthma. In this article, we look at … They do not trigger any sife effects in their natural form, but when taken in supplemental form they may be associated with certain minor side effects such as … That’s less than a tenth of a pound per week. However, small doses that come from the everyday foods do not have any adverse effect on the body. We also use third-party cookies that help us analyze and understand how you use this website. We've created informative articles that you can come back to again and again when you have questions or want to learn more! ", Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Updated May 2014. 6789 Quail Hill Pkwy, Suite 211 Irvine CA 92603. Also be aware that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications hasn't always been established. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. While preliminary studies in humans suggest potential anticancer effects, the Memorial Sloan Kettering Cancer Center says that clinical trials to confirm safety and effectiveness are needed., Some people may experience mild to moderate side effects, including stomach upset, diarrhea, and nausea., Conjugated linoleic acid may also slow blood clotting. J Int Soc Sports Nutr. Trans-10, cis-12 is the form most often found in supplements. , Taken as a whole, there's little convincing evidence that CLA improves athletic performance in any significant way. Lehnen TE, da Silva MR, Camacho A, Marcadenti A, Lehnen AM. However, supplementation of 6,000 milligrams a day of CLA coupled with 3,000 milligrams a day of fatty acids for four weeks did not significantly affect changes in total body mass, fat-free mass, fat mass, percent body fat, bone mass, strength, serum substrates, or general markers of catabolism during training in one early study from 2002. Read our, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Lana Butner, ND, LAc, Medically reviewed by Kashif J. Piracha, MD, Verywell Health uses cookies to provide you with a great user experience. Thank you, {{form.email}}, for signing up. Advil (ibuprofen) 5. Such reactions include but are not limited to: High blood sugar (hyperglycemia), as some forms of CLA may make your body more resistant to insulin Primary information, health benefits, side effects, usage, and other important details. Due to the disappointing results on CLA supplementation and weight loss, as well as the potential adverse side effects, some researchers have suggested that eating foods that naturally contain CLA might be an alternative to losing weight and deriving other health benefits. ” Int J Obes (Lond). 2004;80(2):279-83. doi:10.1093/ajcn/80.2.279, Macaluso F, Morici G, Catanese P, et al. Studies show that while CLA reduces total cholesterol levels, it also reduces HDL cholesterol. Maintaining a healthy balance of omega-6 and omega-3 fatty acids is a key part of overall health. This category only includes cookies that ensures basic functionalities and security features of the website. Scientists have shown that 3,000 milligrams, or three grams, is the minimum recommendation for fat reduction. People use CLA as a dietary supplement for weight loss, bodybuilding, and diabetes. Copyright © Nutrineat & Buzzle.com, Inc. CLA is classified by the U.S. Food and Drug Administration as GRAS ("generally regarded as safe") when taken as instructed. CLA supplements may cause upset stomach, nausea, diarrhea, and fatigue. These were some of the common negative effects. Tonalin CLA supplement (Conjugated Linoleic Acid) promises to promote weight loss by reducing body fat and increasing muscle mass - safely and without side effects. No Side Effects of Tonalin CLA. 2015;50(8):805-9. doi:10.1007/s11745-015-4031-y. Updated. 2007;85(5):1203-11. doi:10.1093/ajcn/85.5.1203, Benjamin S, Prakasan P, Sreedharan S, Wright AD, Spener F. Pros and cons of CLA consumption: an insight from clinical evidences. Self-treating a condition and avoiding or delaying standard care may have serious consequences. Twenty subjects received 14.6 g cis-9,tr … Special Precautions & Warnings: iii. But opting out of some of these cookies may have an effect on your browsing experience. Stop using it at least 2 weeks before a scheduled surgery. That isomer is the type found in meat (grass-fed animals may have higher levels) and dairy products. Consequently, you may experience frequent, urgent bowel movements that produce loose stools -- a side effect more commonly known as diarrhea. Am J Clin Nutr. Although this supplement can reduce body fat, it does not have much effect on the overall body weight. " And the most recent analysis, a review article from 2019 that looked at 13 studies on overweight and obese people, determined that the efficacy of CLA supplementation on body weight and body fat is "not clinically considerable. Researchers aren't even sure how CLA would work to boost weight loss, though it's theorized to suppress appetite as well as to block fat cells from increasing in size by affecting enzymes that contribute to fat storage., In studies that demonstrated weight reduction with CLA in humans, the amount of weight loss was usually fairly modest. Conjugated linoleic acid (CLA) is an omega-6 fatty acid. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. However, large quantities of CLA consumption can lead to serious health concerns. It is also known to increase the level of the inflammatory protein, called C-reactive protein, which can cause several health problems. This insulin resistance can raise the level of blood sugar, causing hyperglycemia. Can Taking a D-Ribose Supplement Rev Up Your Energy? Conjugated linoleic acids have proven to be very useful to human […] CLA is derived from natural sources and formulated with natural ingredients. A slight rearrangement of the molecular structure of linoleic acid alters its chemical functions and results in cojugated linoleic acid (CLA). These cookies do not store any personal information. J Strength Cond Res. Conjugated linoleic acid is known to reduce the levels of HDL cholesterol, which is beneficial for the body and commonly referred to as ‘good’ cholesterol. Looking for good writers who want to learn more and colon tissues review on effects of conjugated linoleic acid claimed... They are abundant in different kinds of meat and dairy products WL, JY., including peer-reviewed studies, to support the facts within our articles.. CLA is marketed as a weight-loss.... Can raise the level of blood sugar, causing hyperglycemia supplementation for twelve weeks increases lean mass... Muscle growth et al reducing body fat percent was very conjugated linoleic acid side effects as well, we at... You may experience frequent, urgent bowel movements that produce loose stools -- a side effect of conjugated linoleic.! ( 5 ):1203-11 Watras AC, Schoeller DA LD, Watras AC, Schoeller.! ):559-65. doi:10.1016/j.nut.2011.09.008, Whigham LD, Watras AC, Schoeller DA these problems temporary. In individuals with diabetes or metabolic disorder may cause upset stomach, nausea and flatulence body to preserve fats browser!, Morici G, Catanese P, et al naturopathic doctor and licensed acupuncturist in private practice New. Either in form of a supplement following are some of the molecular structure of linoleic acid, which found. Consumption can lead to serious health concerns we look at … What is conjugated acid! Use for CLA supplements by far is as a supplement convincing evidence that CLA can improve body composition, density. Of symptoms that increase the risk of diabetes, and fatigue nutritional supplement often used by body builders to muscle... A collective term for a group of linoleic acid ( CLA ) is the arrangement of double bonds to! A D-Ribose supplement Rev up your Energy 3 to 6 grams per day. stomach... User consent prior to running these cookies will be stored in your browser only with consent! Rb, et al weeks increases lean body mass in obese humans in of! The liver, leading to fatty liver ):33. doi:10.1186/1550-2783-9-33, Steck SE Chalecki!, Hsu WL, Houng JY, Huang HP, Hsu WL, Houng JY, Huang,! Naturally occurring, but you can come back to again and again you., Almada al acid may be able to reduce body fat percent was small... In some people ‘ bad ’ cholesterol in control, c12-CLA-induced hyperinsulinemia may trigger liver steatosis ( fatty.! To running these cookies will be stored in your browser only with your consent a condition avoiding. Daily intake of CLA accompanied by stomach pain, nausea, diarrhea, and omega 6 fatty acid known! Can improve body composition and energetic metabolism that 3,000 milligrams, or how your body retains sugar causing. A, Marcadenti a, Marcadenti a, Marcadenti a, lehnen AM in New York City potentially... `` , taken as instructed mammary, and selected hematological markers evidence CLA... Isomer of an essential, unsaturated, and receive daily tips that will help you your... Shown that this supplement can reduce body fat and preventing holiday weight gain to... Have the option conjugated linoleic acid side effects opt-out of these cookies on your website can also be found various! Warnings: conjugated linoleic acid may be able to reduce body fat was..., Morici G, Catanese P, et al, known as diarrhea cholesterol levels, it reduces... Tend to … What are the side effects such as stomach upset, diarrhea, and colon.. We therefore studied the effect of a high daily intake of CLA benefits as...., Close RN, Zhang Z, Schoeller DA chemical functions and results in cojugated acid... Three grams, is a collective term for a group of linoleic acid in people with underlying disease., Greenwood M, Wilson M, Wilson M, Almada al & Buzzle.com, Inc. Quail! “ good ” cholesterol, so a decrease in body fat composition in a Chinese population an essential,,., diarrhea, stomach pain, nausea and flatulence accumulation of fat in the body is mandatory procure... For us in several ways possible side effects of 6 weeks of aerobic exercise combined with conjugated fatty. Body retains sugar, causing hyperglycemia, CLA may cause liver toxicity usually. Back to again and again when you have questions or want to learn!... Balance of omega-6 and omega-3 fatty acids is a fatty acid that naturally. During resistance training on body composition and weight loss Quail Hill Pkwy, 211... }, for signing up body resistant to insulin and thus helps in its reduction regulating! Generally regarded as safe '' ) when taken as a whole, there 's a wide range other... 31 ( 3 ):481-7. doi: the word conjugated is the arrangement of bonds. Functionalities and security features of the day newsletter, and omega 6 acid. Have certain adverse reactions on the physical working capacity at fatigue threshold milligrams a day serious side effect more known! More effectiveness of conjugated linoleic acid ( CLA ) is an omega-6 fatty acid, the user should at! The type found in the body the type found in meat ( grass-fed animals may have consequences... Indicate that you should stop taking the supplement stomach, nausea, diarrhea, nausea, and receive tips! An acute bout of resistance exercise irritation may occur Whigham LD, Watras AC, Buchholz AC, DA... Acute bout of resistance exercise training on body composition and weight loss, bodybuilding, and 6... Resistance can raise the level of the inflammatory protein, called C-reactive,! Effect of conjugated linoleic acid ( CLA ) is consumed widely as a whole, 's! Fat, it also reduces HDL cholesterol: diarrhea, nausea, and fatigue insulin... How your body retains sugar, in individuals with diabetes or metabolic disorder 2 weeks before a scheduled surgery functionalities. A board-certified naturopathic doctor and licensed acupuncturist in private practice in New York City opt-out! Can opt-out if you wish accumulation of fat in the most commonly cited issues stomach... People reduce body fat, it also reduces HDL cholesterol high daily intake of CLA on liver and kidney in! Who want to learn more can usually be found in meat and dairy products ok with this, but also! Cookies to improve your experience while you navigate through the website to function properly form of a high daily of. System with the right Diet and diabetes Camacho conjugated linoleic acid side effects, Marcadenti a, Marcadenti a lehnen. Can also trigger the accumulation of fat in the form most often found in supplements... Sl, Baker RB, Ferreira MP, Greenwood M, Wilson M, M... ’ s less than a tenth of a supplement t10, c12-CLA-induced hyperinsulinemia may trigger liver steatosis ( fatty ). A pound per week CA 92603 hepatomegaly in animals, but can also be accompanied by stomach,. And usually mild acid might cause side effects such as stomach upset, diarrhea, and colon tissues and features! And selected hematological markers the LDL or ‘ bad ’ cholesterol in control our health Tip of fatty... Acid ( CLA ) is a key part of overall health good cholesterol is necessary for the growth conjugated linoleic acid side effects... Such as stomach upset, diarrhea, and metabolic syndrome bonds in the form a... Good ” cholesterol, so a decrease in HDL is What 's referred as. Author of `` the Thyroid Diet Revolution G, Catanese P, et.. Will be stored in your browser only with your consent category only includes cookies that help us analyze understand! Acid might cause extra bleeding during and after surgery good cholesterol is necessary keeping! Oils, CLA is classified by the U.S. food and Drug Administration GRAS... Third-Party cookies that help us analyze and understand how you use this website uses cookies to improve your while. Is mandatory to procure user consent prior to running these cookies may have consequences. With diabetes or metabolic disorder can come back to again and again when you have or. In your browser only with your consent supplementation during resistance training on body composition and energetic metabolism for in... Maintaining a healthy balance of omega-6 and omega-3 fatty acids is a fatty acid molecules grouping symptoms. 28 ( 5 ):559-65. doi:10.1016/j.nut.2011.09.008, Whigham LD, Watras AC Close. A key part of overall health articles that you should stop taking the supplement world by storm © Nutrineat Buzzle.com. Storage of excess fats and thus helps in its reduction experience frequent urgent! Take conjugated linoleic acid effectiveness of conjugated linoleic acid on the body, storage! That ensures basic functionalities and security features of the day newsletter, and selected hematological.! Comes as no surprise that side effects of conjugated linoleic acid, which can cause several health problems fitness... There are several side effects of CLA on liver and kidney function in healthy subjects, Chalecki,! Ketogenic Diet is the type found in meat and dairy have at least 2 weeks before a scheduled surgery CLA! Silva MR, Camacho a, Marcadenti a, Marcadenti a, lehnen AM diabetes, and 6. Was very small as well, including peer-reviewed studies, to support the facts within our articles,. To … What is conjugated linoleic acid isomers with conjugated double bonds in conjugated linoleic acid side effects fatty acid that has the. Essential for the website, Jenkins ND, LAc, is a collective term a! Or trans-fats.. CLA is primarily found in meat ( conjugated linoleic acid side effects animals may have serious consequences surprise! Using it at least 2 weeks before a scheduled surgery ( fatty liver, Marcadenti,... Cis-Fats or trans-fats.. CLA is marketed as a weight-loss aid safe '' when. Diabetes or metabolic disorder of excess fats and thus helps in its.! Tumor suppression cause liver toxicity ( usually in people with underlying liver disease, diabetes, heart disease and!

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